Pharmacogenomics An Introduction and Clinical Perspective
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Section I. General Concepts
1. Developing Perspectives on Pharmacogenomics
2. Genetic Concepts of Pharmacogenomics: Basic Review of DNA, Genes, Polymorphisms, Haplotypes and Nomenclature
3. Analytical Methods to Identify Genetic Variations and Bioinformatics
4. Regulatory Considerations in Pharmacogenomics at EMA and US FDA
5. Ethical, Legal, and Social Issues Associated with Pharmacogenomics
6A. Pharmacogenetics of Cytochrome P450
6B. Phase II Drug-Metabolizing Enzymes
7. Drug Transporters
8. Nongenetic Influences on Drug Metabolism
9. Public Access to Pharmacogenomic Testing and Patient Counseling
10. Understanding the Use of Pharmacoeconomic Analysis to Assess the Economic Impact of Pharmacogenomic Testing
Section II. Clinical Application of Pharmacogenomics
11. Cardiovascular Pharmacogenomics
12. Pharmacogenomics and Pharmacogenetics for Infectious Diseases
13. Pharmacogenomics in Oncology
14. Psychiatry and Addiction Medicine
15. Immunology,Transplantation,and Vaccines
16. Pharmacogenomics in Neurology
17A. Pharmacogenomics of Gastrointestinal Drugs: Focus on Proton Pump Inhibitors
17B. Genomics and the Kidney
Index
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A COMPLETE INTRODUCTORY TEXT TO THE FIELD OF PHARMACOGENOMICS
A Doody's Core Title for 2017!
The only pharmacogenomics resource to feature a global author team comprised of PharmDs, MDs, PhDs and social scientists, Pharmacogenomics offers an essential, highly accessible survey of this dynamic discipline. You will find thorough coverage of all need-to-know topics, from individual molecules to systemic diseases, plus anexamination of the latest technologies that are constantly reshaping the field. Pharmacogenomics is cohesively organized into two sections, the first of which reviewsbasic aspects of pharmacogenomics, including ethics, regulatory, science, and drug metabolism, along with a "mini" course in molecular genetics and testing. The second section highlights the practical application of pharmacogenomics in cardiovascular medicine, immunology, neurology, and other specialties.
FEATURES
- Important overview of general pharmacogenomics and pharmacogenetics concepts, including geneticvariation in signal transduction and targets, plus a review of the genetic concepts of pharmacogenomics
- Discussion of regulatory considerations in pharmacogenomics
- Focus on the role of health care professionals along with a review of related privacy issues,as well as broader ethical, legal, and social considerations
- In-depth chapters on drug metabolism and transporters
- Practical, step-by-step guidance on public access to pharmacogenomic testing and patient counseling
- Up-to-date coverage of non-genetic influences on pharmacogenomics
- Emphasis on gene-drug interactions
- Numerous tables and figures
- Chapter-ending references
- Concise learning objectives at the beginning of each chapter
- Case studies to familiarize you with the clinical relevance of pharmacogenomics in each specialty