Clinical Pharmacokinetics Handbook

Overview

Designed for pharmacists and clinicians responsible for adjusting drug dosages based on the patient blood serum concentrations and other parameters, this indispensable, portable reference offers a variety of ways to perform pharmacokinetic calculations. Features calculation methods, algorithms for choosing the best calculation method, and case studies.

Table of contents

Part I: Basic Concepts
1. Clinical Pharmacokinetic and Pharmacodynamic Concepts
2. Clinical Pharmacokinetic Equations and Calculations
3. Drug Dosing in Special Populations: Renal and Hepatic Disease, Dialysis, Heart Failure, Obesity, and Drug Interactions

Part II: Antibiotics

4. Aminoglycoside Antibiotics
5. Vancomycin

Part III: Cardiovascular Agents

6. Digoxin
7. Lidocaine
8. Procainamide and N-Acetyl Procainamide
9. Quinidine

Part IV: Anticonvulsants

10. Phenytoin
11. Carbamazepine
12. Valproic Acid
13. Phenobarbital/Primidone
14. Ethosuximide

Part V: Immunosuppressants

15. Cyclosporine
16. Tacrolimus (FK560)

Part VI: Other Drugs

17. Lithium
18. Theophylline

Biographical note

Larry Bauer, Pharm.D. is a Professor at the University of Washington School of Pharmacy and has been on the faculty since 1980. Dr. Bauer is a fellow of the American College of Clinical Pharmacology and the American College of Clinical Pharmacy. Dr. Bauer's specialty area is in clinical pharmacokinetics, and he teaches courses and offers clinical clerkships in this area. He is the author of Applied Clinical Pharamcokinetics (McGraw-Hill, 2001).

Back cover copy

Clinical Pharmacokinetics Handbook
Larry A. Bauer, Pharm.D., F.C.C.P., F.C.P.

The ideal on-the-spot reference for clinicians who design initial pharmacokinetic drug regimens, and especially valuable for those who modify dosages based on serum concentrations and other monitoring parameters.

Perfect for bedside use, this indispensable, easy-to-carry Handbook provides:

• Ready access to a variety of user-friendly calculation methods, appropriate to differing circumstances and needs
• Algorithms that simplify selection of the right calculation procedure
• Up-to-date coverage of the latest techniques and equations for pharmacokinetically monitored drugs
• Patient-specific regimen and monitoring criteria for each referenced drug
• Essential information on drug dosing in special populations, including patients with renal and hepatic disease, obesity, and heart failure
• Drug-by-drug coverage
• An abundance of tables, charts, and nomograms that make actual calculations often unnecessary
• Numerous case scenarios that aid the clinician in understanding how calculations are selected, applied, and worked
• A concise review of basic clinical pharmacokinetic and pharmacodynamic principles


Reviews of Larry A. Bauer's Applied Clinical Pharmacokinetics

" ... Written by an in-the-trenches clinical pharmacist ... focuses on the practical application of pharmacokinetics in patient care."
—Bethesda, Maryland pharmacist, online

"Many pharmacokinetic residents and fellows live by this book, and it came highly recommended to me by experienced clinicians."
—Online pharmacist review

"An excellent resource of pharmacokinetic information for students and clinicians ... presented in a more student-friendly manner with extensive explanations and example problems."
—Doody Review Services