Applied Biopharmaceutics & Pharmacokinetics

Overview

The most comprehensive text on the practical applications of biopharmaceuticals and pharmacokinetics!

4 STAR DOODY'S REVIEW!
"The updated edition provides the reader with a solid foundation in the basic principles of pharmacokinetics and biopharmaceutics. Students will be able to apply the information to their clinical practice and researchers will find this to be a valuable reference. This modestly priced book should be the gold standard for student use."--Doody's Review Service

The primary emphasis of this book is on the application and understanding of concepts. Basic theoretical discussions of the principles of biopharmaceutics and pharmacokinetics are provided, along with illustrative examples and practice problems and solutions to help the student gain skill in practical problem solving.

Table of contents

Preface

Glossary

Chapter 1 Introduction to Biopharmaceutics and Pharmacokinetics

Chapter 2 Mathematic Fundamentals in Pharmacokinetics

Chapter 3 One Compartment Open Model – IV Bolus Injection

Chapter 4 Multicompartmental Models – IV Bolus Injection

Chapter 5 Intravenous Infusion

Chapter 6 Drug Elimination and Clearance

Chapter 7 Pharmacokinetics of Oral Absorption

Chapter 8 Multiple Dosage Regimens

Chapter 9 Nonlinear Pharmacokinetics

Chapter 10 Physiologic Drug Distribution and Protein Binding

Chapter 11 Renal and Hepatic Elimination of Drugs

Chapter 12 Pharmacogenetics - NEW

Chapter 13 Physiologic Factors Related to Drug Absorption

Chapter 14 Biopharmaceutic Considerations in Drug Product Design

Chapter 15 Bioavailability and Bioequivalence

Chapter 16 Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy - NEW

Chapter 17 Modified Release Drug Products and Drug Devices

Chapter 18 Targeted Drug Delivery Systems and Biotechnology Products

Chapter 19 Relationship between Pharmacokinetic and Pharmacodynamics

Chapter 20 Application of Pharmacokinetics in Clinical Situations

Chapter 21 Dosage Adjustment in Renal and Hepatic Disease

Chapter 22 Physiological Pharmacokinetic Models, Mean Resident Time and Statistical Moment Theory

Appendix A Statistics

Appendix B Applications of Computers in Pharmacokinetics

Appendix C Ethical Considerations

Appendix D Solutions to Frequently Asked Questions (FAQ) and Learning Questions

Appendix E Popular Drugs and Pharmacokinetic Parameters

Biographical note

Leon Shargel, PhD is vice president of biopharmaceutics at Eon Labs, Inc. Wilson, NC., Susanna Wu-Pong, PhD, RPh is an associate professor in the department of pharmaceutics at Virginia Commonwealth University, Richmond, Virginia, Andrew B.C. Yu,PhD, RPh, formerly a professor at the Albany College of Pharmacy, is currently with the FDA in Rockville, MD.

Back cover copy

The Best Way to Learn Biopharmaceutics and Pharmacokinetics.

Applied Biopharmaceutics and Pharmacokinetics provides the reader with a basic understanding of the principles of biopharmaceutics and pharmacokinetics as applied to drug product development and drug therapy. The revised and updated fifth edition of this popular text remains unique in teaching the student the basic concepts that may be applied to understanding the complex issues associated with the processes of drug delivery and the essentials of safe and effective drug therapy.

NEW TO THIS EDITION:
*Chapter on Pharmacogenetics
*Explanation of the role of pharmacogenetics in drug metabolism using examples of drugs that frequently lead to drug interactions
*Chapter on the Impact of Biopharmaceutics on Drug Product Quality and Clinical Efficacy
*Enhanced applications to pharmacy practice with the emphasis on biopharmaceutics, pharmacokinetics and drug delivery
*Updated coverage of dosing in clinical situations including dosing in special populations and what to do with a skipped dose in patients
*Additional practice problems and clinical examples
*Newest concepts in biopharmaceutics and pharmacokinetics
*Reorganized content to follow today's curriculum in pharmaceutical sciences

" ... An excellent book on biopharmaceutics and pharmacokinetics ... recommended not only for the newcomer, but as a valuable reference in any library."
—Online reader review of the previous edition